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KMID : 1098420050130010041
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Korean Journal of Medicinal Crop Science
2005 Volume.13 No. 1 p.41 ~ p.47
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Anticancer and Immune Activities of the Extracts from Amorpha fruticosa L
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Kim Jung-Hwa
Kim Dae-Ho
You Jin-Hyun
Kwon Min-Cheol
Lee Hyun-Jung
Lee Hak-Ju
Lee Hyeon-Yong
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Abstract
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This study was performed to experiment about useful biological activities of the parts of the extracts from Amorpha fruticosa LINNE. Experimental studies were progressed through the anticancer activities and immune activities such as cell cytotoxicity, inhibition activities of cell growth, cell growth of human B and T cell, productivity of cytokines and natural killer cell activities. The cell cytotoxicity using human Lung normal cell (HEL299) was showed cytotoxicity of below 22% by extracts of Amorpha fruticosa L. in 1.0 g/l concentration. The anticancer activities were increased in over 70% by roots extracts of Amorpha fruticosa L. in A549 and AGS cells. The immune cell growth using human immune B and T cells was increased against control by barks extracts of Amorpha fruticosa L. The secretion of cytokines (IL-6,;TNF-{alpha}) from human immune B and T cells was showed secretion of the amount of cytokines by roots extracts of Amorpha fruticosa L. Also NK cell growth was increased against control all of the extracts of Amorpha fruticosa L. From the results, the roots and barks extracts of Amorpha fruticosa L. were showed useful biological activities.
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KEYWORD
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Amorpha fruticosa LINNE., biological activity, anticancer activity, immune activity, cytokine, NK cell
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